› 1gzz

X-ray diffraction
2.3Å resolution

Human Insulin-like growth factor; Hamburg data

Released:
DOI: 10.2210/pdb1gzz/pdb
PDB entry 1gzz coloured by chain, front view.
PDB entry 1gzz coloured by chain, side view.
PDB entry 1gzz coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural origins of the functional divergence of human insulin-like growth factor-I and insulin.
Brzozowski AM, Dodson EJ, Dodson GG, Murshudov GN, Verma C, Turkenburg JP, de Bree FM, Dauter Z
Biochemistry 41 9389-97 (2002)
PMID: 12135360

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138312 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Insulin-like growth factor I Chain: B
Molecule details ›
Chain: B
Length: 70 amino acids
Theoretical weight: 7.66 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P05019 (Residues: 49-118; Coverage: 40%)
Gene names: IBP1, IGF1
Sequence domains: Insulin/IGF/Relaxin family
Structure domains: Insulin-like

Ligands and Environments

1 bound ligand:
Ligand C15 1 x C15
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: EMBL/DESY, HAMBURG BEAMLINE BW7B
Spacegroup: C2221
Unit cell:
a: 30.723Å b: 69.282Å c: 64.528Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.238 0.234 0.275
Expression system: Escherichia coli

Quick links

Citations

9 review citations

Structural biology of insulin and IGF1 receptors: implications for drug design.
De Meyts et al. (2002)
8 more

2 mentions without citation

Ensemble MD simulations restrained via crystallographic data: accurate structure leads to accurate dynamics.
Xue et al. (2014)
1 more