› 1h4o

X-ray diffraction
1.95Å resolution

Monoclinic form of human peroxiredoxin 5

Released:
DOI: 10.2210/pdb1h4o/pdb
PDB entry 1h4o coloured by chain, front view.
PDB entry 1h4o coloured by chain, side view.
PDB entry 1h4o coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of human peroxiredoxin 5, a novel type of mammalian peroxiredoxin at 1.5 A resolution.
Declercq JP, Evrard C, Clippe A, Stricht DV, Bernard A, Knoops B
J Mol Biol 311 751-9 (2001)
PMID: 11518528

Function and Biology Details

Reaction catalysed: 
Thioredoxin + ROOH = thioredoxin disulfide + H(2)O + ROH
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151615 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peroxiredoxin-5, mitochondrial Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 161 amino acids
Theoretical weight: 16.92 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli M15
UniProt:
  • Canonical: P30044 (Residues: 54-214; Coverage: 75%)
Gene names: ACR1, PRDX5, SBBI10
Sequence domains: Redoxin
Structure domains: Glutaredoxin

Ligands and Environments

1 bound ligand:
Ligand BEZ 8 x BEZ
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE BM30A
Spacegroup: P21
Unit cell:
a: 130.79Å b: 66.49Å c: 141.24Å
α: 90° β: 117.54° γ: 90°
R-values:
R R work R free
0.166 0.165 0.19
Expression system: Escherichia coli M15

Quick links

Citations

24 review citations

Structure, mechanism and regulation of peroxiredoxins.
Wood et al. (2003)
23 more

7 mentions without citation

Structure-based insights into the catalytic power and conformational dexterity of peroxiredoxins.
Hall et al. (2011)
6 more