› 1h6g

X-ray diffraction
2.2Å resolution

alpha-catenin M-domain

Released:
DOI: 10.2210/pdb1h6g/pdb
PDB entry 1h6g coloured by chain, front view.
PDB entry 1h6g coloured by chain, side view.
PDB entry 1h6g coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of the M-fragment of alpha-catenin: implications for modulation of cell adhesion.
Yang J, Dokurno P, Tonks NK, Barford D
EMBO J 20 3645-56 (2001)
PMID: 11447106

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-152826 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Catenin alpha-1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 256 amino acids
Theoretical weight: 28.88 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P35221 (Residues: 377-632; Coverage: 28%)
Gene name: CTNNA1
Sequence domains: Vinculin family
Structure domains: Alpha-catenin/vinculin-like

Ligands and Environments

3 bound ligands:
Ligand MPD 1 x MPD
Ligand CA 2 x CA
Ligand CL 1 x CL
1 modified residue:
Ligand MSE 14 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: SRS BEAMLINE PX14.1
Spacegroup: P21
Unit cell:
a: 42.863Å b: 85.703Å c: 75.481Å
α: 90° β: 100.47° γ: 90°
R-values:
R R work R free
0.193 0.193 0.257
Expression system: Escherichia coli

Quick links

Citations

9 review citations

Structure and mechanism of cadherins and catenins in cell-cell contacts.
Pokutta et al. (2007)
8 more

11 mentions without citation

Ca2+ regulation of ion transport in the Na+/Ca2+ exchanger.
Hilge M. (2012)
10 more