› 1h8f

X-ray diffraction
2.8Å resolution

Glycogen Synthase Kinase 3 beta.

Released:
DOI: 10.2210/pdb1h8f/pdb
PDB entry 1h8f coloured by chain, front view.
PDB entry 1h8f coloured by chain, side view.
PDB entry 1h8f coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of glycogen synthase kinase 3 beta: structural basis for phosphate-primed substrate specificity and autoinhibition.
Dajani R, Fraser E, Roe SM, Young N, Good V, Dale TC, Pearl LH
Cell 105 721-32 (2001)
PMID: 11440715

Function and Biology Details

Reactions catalysed: 
ATP + a protein = ADP + a phosphoprotein
ATP + [tau protein] = ADP + [tau protein] phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156061 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glycogen synthase kinase-3 beta Chains: A, B
Molecule details ›
Chains: A, B
Length: 352 amino acids
Theoretical weight: 39.8 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P49841 (Residues: 35-386; Coverage: 84%)
Gene name: GSK3B
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand EPE 2 x EPE
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SRS BEAMLINE PX14.2
Spacegroup: P212121
Unit cell:
a: 83.199Å b: 86.06Å c: 178.093Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.22 0.22 0.256
Expression system: Spodoptera frugiperda

Quick links

Citations

92 review citations

AKT/PKB Signaling: Navigating the Network.
Manning et al. (2017)
91 more

27 mentions without citation

Substrate and docking interactions in serine/threonine protein kinases.
Goldsmith et al. (2007)
26 more