› 1h8u

X-ray diffraction
1.8Å resolution

Crystal Structure of the Eosinophil Major Basic Protein at 1.8A: An Atypical Lectin with a Paradigm Shift in Specificity

Released:
DOI: 10.2210/pdb1h8u/pdb
PDB entry 1h8u coloured by chain, front view.
PDB entry 1h8u coloured by chain, side view.
PDB entry 1h8u coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of the eosinophil major basic protein at 1.8 A. An atypical lectin with a paradigm shift in specificity.
Swaminathan GJ, Weaver AJ, Loegering DA, Checkel JL, Leonidas DD, Gleich GJ, Acharya KR
J Biol Chem 276 26197-203 (2001)
PMID: 11319227

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-146734 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Eosinophil granule major basic protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 117 amino acids
Theoretical weight: 13.82 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P13727 (Residues: 106-222; Coverage: 57%)
Gene names: MBP, PRG2
Sequence domains: Lectin C-type domain
Structure domains: Mannose-Binding Protein A, subunit A

Ligands and Environments

2 bound ligands:
Ligand SO4 8 x SO4
Ligand GOL 2 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SRS BEAMLINE PX14.1
Spacegroup: C2
Unit cell:
a: 74.328Å b: 57.487Å c: 60.961Å
α: 90° β: 113.2° γ: 90°
R-values:
R R work R free
0.234 0.234 0.264

Quick links

Citations

8 review citations

Eosinophils: multifaceted biological properties and roles in health and disease.
Kita H. (2011)
7 more

10 mentions without citation

Eosinophil granule proteins: form and function.
Acharya et al. (2014)
9 more