› 1ha1

X-ray diffraction
1.75Å resolution

HNRNP A1 (RBD1,2) FROM HOMO SAPIENS

Released:
DOI: 10.2210/pdb1ha1/pdb
PDB entry 1ha1 coloured by chain, front view.
PDB entry 1ha1 coloured by chain, side view.
PDB entry 1ha1 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of the two RNA binding domains of human hnRNP A1 at 1.75 A resolution.
Shamoo Y, Krueger U, Rice LM, Williams KR, Steitz TA
Nat Struct Biol 4 215-22 (1997)
PMID: 9164463

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140720 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed Chain: A
Molecule details ›
Chain: A
Length: 184 amino acids
Theoretical weight: 21.05 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P09651 (Residues: 1-184; Coverage: 50%)
Gene names: HNRNPA1, HNRPA1
Sequence domains: RNA recognition motif
Structure domains: Alpha-Beta Plaits

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X12C
Spacegroup: P21
Unit cell:
a: 37.6Å b: 43.5Å c: 55.5Å
α: 90° β: 94.7° γ: 90°
R-values:
R R work R free
0.198 0.198 0.275
Expression system: Escherichia coli

Quick links

Citations

18 review citations

Mechanical devices of the spliceosome: motors, clocks, springs, and things.
Staley et al. (1998)
17 more

15 mentions without citation

Heterogeneous nuclear ribonucleoproteins (hnRNPs) in cellular processes: Focus on hnRNP E1's multifunctional regulatory roles.
Chaudhury et al. (2010)
14 more