› 1haf

Solution NMR

HEREGULIN-ALPHA EPIDERMAL GROWTH FACTOR-LIKE DOMAIN, NMR, MINIMIZED AVERAGE STRUCTURE

Released:
DOI: 10.2210/pdb1haf/pdb
PDB entry 1haf coloured by chain, front view.
PDB entry 1haf coloured by chain, side view.
PDB entry 1haf coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
High-resolution solution structure of the EGF-like domain of heregulin-alpha.
Jacobsen NE, Abadi N, Sliwkowski MX, Reilly D, Skelton NJ, Fairbrother WJ
Biochemistry 35 3402-17 (1996)
PMID: 8639490

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-169705 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Neuregulin-1 Chain: A
Molecule details ›
Chain: A
Length: 63 amino acids
Theoretical weight: 7.13 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q02297 (Residues: 177-239; Coverage: 10%)
Gene names: GGF, HGL, HRGA, NDF, NRG1, SMDF
Sequence domains: EGF-like domain
Structure domains: Laminin

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Expression system: Escherichia coli

Quick links

Citations

5 review citations

Molecular mechanisms underlying ErbB2/HER2 action in breast cancer.
Harari et al. (2000)
4 more

2 mentions without citation

Direct binding of the EGF-like domain of neuregulin-1 to integrins ({alpha}v{beta}3 and {alpha}6{beta}4) is involved in neuregulin-1/ErbB signaling.
Ieguchi et al. (2010)
1 more