› 1hak

X-ray diffraction
3Å resolution

CRYSTAL STRUCTURE OF RECOMBINANT HUMAN PLACENTAL ANNEXIN V COMPLEXED WITH K-201 AS A CALCIUM CHANNEL ACTIVITY INHIBITOR

Released:
DOI: 10.2210/pdb1hak/pdb
PDB entry 1hak coloured by chain, front view.
PDB entry 1hak coloured by chain, side view.
PDB entry 1hak coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of annexin V with its ligand K-201 as a calcium channel activity inhibitor.
Kaneko N, Ago H, Matsuda R, Inagaki E, Miyano M
J Mol Biol 274 16-20 (1997)
PMID: 9398511

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140373 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Annexin A5 Chains: A, B
Molecule details ›
Chains: A, B
Length: 320 amino acids
Theoretical weight: 35.98 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P08758 (Residues: 1-320; Coverage: 100%)
Gene names: ANX5, ANXA5, ENX2, PP4
Sequence domains: Annexin
Structure domains: Annexin

Ligands and Environments

1 bound ligand:
Ligand K21 2 x K21
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RUH3R
Spacegroup: P63
Unit cell:
a: 99.3Å b: 99.3Å c: 130.5Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.206 0.206 0.331
Expression system: Escherichia coli

Quick links

Citations

7 review citations

Annexins: from structure to function.
Gerke et al. (2002)
6 more

4 mentions without citation

LIGSITEcsc: predicting ligand binding sites using the Connolly surface and degree of conservation.
Huang et al. (2006)
3 more