› 1hcp

Solution NMR

DNA RECOGNITION BY THE OESTROGEN RECEPTOR: FROM SOLUTION TO THE CRYSTAL

Released:
DOI: 10.2210/pdb1hcp/pdb
PDB entry 1hcp coloured by chain, ensemble of 30 models, front view.
PDB entry 1hcp coloured by chain, ensemble of 30 models, side view.
PDB entry 1hcp coloured by chain, ensemble of 30 models, top view.
Source organism: Homo sapiens
Primary publication:
DNA recognition by the oestrogen receptor: from solution to the crystal.
Schwabe JW, Chapman L, Finch JT, Rhodes D, Neuhaus D
Structure 1 187-204 (1993)
PMID: 16100953

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136903 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Estrogen receptor Chain: A
Molecule details ›
Chain: A
Length: 76 amino acids
Theoretical weight: 8.77 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P03372 (Residues: 180-254; Coverage: 13%)
Gene names: ESR, ESR1, NR3A1
Sequence domains: Zinc finger, C4 type (two domains)
Structure domains: Erythroid Transcription Factor GATA-1, subunit A

Ligands and Environments

1 bound ligand:
Ligand ZN 2 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
Expression system: Escherichia coli

Quick links

Citations

12 review citations

The estradiol pharmacophore: ligand structure-estrogen receptor binding affinity relationships and a model for the receptor binding site.
Anstead et al. (1997)
11 more

7 mentions without citation

Nuclear receptor phosphorylation in xenobiotic signal transduction.
Negishi et al. (2020)
6 more