› 1hkf

X-ray diffraction
2.2Å resolution

The three dimensional structure of NK cell receptor Nkp44, a triggering partner in natural cytotoxicity

Released:
DOI: 10.2210/pdb1hkf/pdb
PDB entry 1hkf coloured by chain, front view.
PDB entry 1hkf coloured by chain, side view.
PDB entry 1hkf coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The three-dimensional structure of the human NK cell receptor NKp44, a triggering partner in natural cytotoxicity.
Cantoni C, Ponassi M, Biassoni R, Conte R, Spallarossa A, Moretta A, Moretta L, Bolognesi M, Bordo D
Structure 11 725-34 (2003)
PMID: 12791260

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-132088 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Natural cytotoxicity triggering receptor 2 Chain: A
Molecule details ›
Chain: A
Length: 122 amino acids
Theoretical weight: 13.96 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O95944 (Residues: 19-130; Coverage: 43%)
Gene names: LY95, NCR2
Sequence domains: Immunoglobulin V-set domain
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE BM30A
Spacegroup: P6222
Unit cell:
a: 60.437Å b: 60.437Å c: 197.253Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.24 0.24 0.245
Expression system: Escherichia coli

Quick links

Citations

14 review citations

Natural killer cells in human health and disease.
Orange et al. (2006)
13 more

7 mentions without citation

Structural basis for recognition of cellular and viral ligands by NK cell receptors.
Li et al. (2014)
6 more