› 1hla

X-ray diffraction
3.5Å resolution

STRUCTURE OF THE HUMAN CLASS I HISTOCOMPATIBILITY ANTIGEN, HLA-A2

Released:
DOI: 10.2210/pdb1hla/pdb
PDB entry 1hla coloured by chain, front view.
PDB entry 1hla coloured by chain, side view.
PDB entry 1hla coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of the human class I histocompatibility antigen, HLA-A2.
Bjorkman PJ, Saper MA, Samraoui B, Bennett WS, Strominger JL, Wiley DC
Nature 329 506-12
PMID: 3309677

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-137702 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
HLA class I histocompatibility antigen, A alpha chain Chain: A
Molecule details ›
Chain: A
Length: 270 amino acids
Theoretical weight: 31.17 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P04439 (Residues: 25-294; Coverage: 79%)
Gene names: HLA-A, HLAA
Sequence domains:
Beta-2-microglobulin Chain: M
Molecule details ›
Chain: M
Length: 97 amino acids
Theoretical weight: 11.5 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P61769 (Residues: 21-117; Coverage: 98%)
Gene names: B2M, CDABP0092, HDCMA22P
Sequence domains: Immunoglobulin C1-set domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P212121
Unit cell:
a: 60.2Å b: 80.4Å c: 112.2Å
α: 90° β: 90° γ: 90°
Expression system: Not provided

Quick links

Citations

525 review citations

Protein folding in the cell.
Gething et al. (1992)
524 more

10 mentions without citation

RCSB Protein Data Bank: Sustaining a living digital data resource that enables breakthroughs in scientific research and biomedical education.
Burley et al. (2018)
9 more