› 1hll

Solution NMR

NMR STRUCTURE OF T3-I2, A 32 RESIDUE PEPTIDE FROM THE ALPHA-2A ADRENERGIC RECEPTOR

Released:
DOI: 10.2210/pdb1hll/pdb
PDB entry 1hll coloured by chain, front view.
PDB entry 1hll coloured by chain, side view.
PDB entry 1hll coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
NMR structure of the second intracellular loop of the alpha 2A adrenergic receptor: evidence for a novel cytoplasmic helix.
Chung DA, Zuiderweg ER, Fowler CB, Soyer OS, Mosberg HI, Neubig RR
Biochemistry 41 3596-604 (2002)
PMID: 11888275

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140425 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Alpha-2A adrenergic receptor Chain: A
Molecule details ›
Chain: A
Length: 32 amino acids
Theoretical weight: 3.8 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P08913 (Residues: 133-164; Coverage: 7%)
Gene names: ADRA2A, ADRA2R, ADRAR

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing in torsion angle space
Expression system: Not provided

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Citations

5 review citations

The crystallographic model of rhodopsin and its use in studies of other G protein-coupled receptors.
Filipek et al. (2003)
4 more

5 mentions without citation

GPCR Conformations: Implications for Rational Drug Design
Parrill et al. (2010)
4 more