› 1hpj

Solution NMR

SOLUTION NMR STRUCTURE OF THE HUMAN PLASMINOGEN KRINGLE 1 DOMAIN COMPLEXED WITH 6-AMINOHEXANOIC ACID AT PH 5.3, 310K, DERIVED FROM RANDOMLY GENERATED STRUCTURES USING SIMULATED ANNEALING, 12 STRUCTURES

Released:
DOI: 10.2210/pdb1hpj/pdb
PDB entry 1hpj coloured by chain, ensemble of 12 models, front view.
PDB entry 1hpj coloured by chain, ensemble of 12 models, side view.
PDB entry 1hpj coloured by chain, ensemble of 12 models, top view.
Source organism: Homo sapiens
Primary publication:
Solution structure of the epsilon-aminohexanoic acid complex of human plasminogen kringle 1.
Rejante MR, Llinás M
Eur J Biochem 221 939-49 (1994)
PMID: 8181476

Function and Biology Details

Reaction catalysed: 
Preferential cleavage: Lys-|-Xaa > Arg-|-Xaa, higher selectivity than trypsin. Converts fibrin into soluble products.
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-133230 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Angiostatin Chain: A
Molecule details ›
Chain: A
Length: 79 amino acids
Theoretical weight: 9.08 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P00747 (Residues: 103-181; Coverage: 10%)
Gene name: PLG
Sequence domains: Kringle domain
Structure domains: Plasminogen Kringle 4

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores

Quick links

Citations

3 review citations

New insights into the structure and function of the plasminogen/plasmin system.
Law et al. (2013)
2 more