› 1hs5

Solution NMR

NMR SOLUTION STRUCTURE OF DESIGNED P53 DIMER

Released:
DOI: 10.2210/pdb1hs5/pdb
PDB entry 1hs5 coloured by chain, ensemble of 20 models, front view.
PDB entry 1hs5 coloured by chain, ensemble of 20 models, side view.
PDB entry 1hs5 coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Structure and functionality of a designed p53 dimer.
Davison TS, Nie X, Ma W, Lin Y, Kay C, Benchimol S, Arrowsmith CH
J Mol Biol 307 605-17 (2001)
PMID: 11254385

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138131 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cellular tumor antigen p53 Chains: A, B
Molecule details ›
Chains: A, B
Length: 34 amino acids
Theoretical weight: 4.11 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P04637 (Residues: 324-357; Coverage: 9%)
Gene names: P53, TP53
Sequence domains: P53 tetramerisation motif

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Escherichia coli

Quick links

Citations

3 review citations

Structural biology of the tumor suppressor p53.
Joerger et al. (2008)
2 more

1 mention without citation

Utilizing NMR to study the structure of growth-inhibitory proteins.
Marassi F. (2003)