› 1huw

X-ray diffraction
2Å resolution

THE CRYSTAL STRUCTURE OF AFFINITY-MATURED HUMAN GROWTH HORMONE AT 2 ANGSTROMS RESOLUTION

Released:
DOI: 10.2210/pdb1huw/pdb
PDB entry 1huw coloured by chain, front view.
PDB entry 1huw coloured by chain, side view.
PDB entry 1huw coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The crystal structure of affinity-matured human growth hormone at 2 A resolution.
Ultsch MH, Somers W, Kossiakoff AA, de Vos AM
J Mol Biol 236 286-99 (1994)
PMID: 8107110

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-134131 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Somatotropin Chain: A
Molecule details ›
Chain: A
Length: 191 amino acids
Theoretical weight: 21.99 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P01241 (Residues: 27-217; Coverage: 100%)
Gene name: GH1
Sequence domains: Somatotropin hormone family
Structure domains: Growth Hormone; Chain: A;

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: C2
Unit cell:
a: 80.45Å b: 59.34Å c: 50.87Å
α: 90° β: 128.2° γ: 90°
R-values:
R R work R free
0.185 0.185 not available
Expression system: Not provided

Quick links

Citations

13 review citations

Interleukin-6: structure-function relationships.
Simpson et al. (1997)
12 more

9 mentions without citation

In search for more accurate alignments in the twilight zone.
Jaroszewski et al. (2002)
8 more