› 1i16

Solution NMR

STRUCTURE OF INTERLEUKIN 16: IMPLICATIONS FOR FUNCTION, NMR, 20 STRUCTURES

Released:
DOI: 10.2210/pdb1i16/pdb
PDB entry 1i16 coloured by chain, ensemble of 20 models, front view.
PDB entry 1i16 coloured by chain, ensemble of 20 models, side view.
PDB entry 1i16 coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Structure of interleukin 16 resembles a PDZ domain with an occluded peptide binding site.
Mühlhahn P, Zweckstetter M, Georgescu J, Ciosto C, Renner C, Lanzendörfer M, Lang K, Ambrosius D, Baier M, Kurth R, Holak TA
Nat Struct Biol 5 682-6 (1998)
PMID: 9699630

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171896 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Interleukin-16 Chain: A
Molecule details ›
Chain: A
Length: 130 amino acids
Theoretical weight: 13.39 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q14005 (Residues: 1203-1332; Coverage: 10%)
Gene name: IL16
Sequence domains: PDZ domain
Structure domains: Pdz3 Domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

6 review citations

PDZ domain proteins: plug and play!
Nourry et al. (2003)
5 more

8 mentions without citation

Recent findings and future directions for interpolar mitotic kinesin inhibitors in cancer therapy.
Myers et al. (2016)
7 more