› 1i3e

X-ray diffraction
1.86Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-159677 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Hemoglobin subunit gamma-1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 146 amino acids
Theoretical weight: 16.03 KDa
Source organism: Homo sapiens
Expression system: Saccharomyces cerevisiae
UniProt:
  • Canonical: P69891 (Residues: 2-147; Coverage: 99%)
Gene names: HBG1, PRO2979
Sequence domains: Globin
Structure domains: Globins

Ligands and Environments

2 bound ligands:
Ligand AZI 2 x AZI
Ligand HEM 2 x HEM
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RUH3R
Spacegroup: P21212
Unit cell:
a: 60.541Å b: 81.625Å c: 53.036Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.184 0.184 0.22
Expression system: Saccharomyces cerevisiae

Quick links

Citations

2 review citations

The pathophysiology of extracellular hemoglobin associated with enhanced oxidative reactions.
Rifkind et al. (2014)
1 more

2 mentions without citation

Oligomerization and ligand binding in a homotetrameric hemoglobin: two high-resolution crystal structures of hemoglobin Bart's (gamma(4)), a marker for alpha-thalassemia.
Kidd et al. (2001)
1 more