› 1i71

X-ray diffraction
1.45Å resolution

HIGH RESOLUTION CRYSTAL STRUCTURE OF APOLIPOPROTEIN(A) KRINGLE IV TYPE 7: INSIGHTS INTO LIGAND BINDING

Released:
DOI: 10.2210/pdb1i71/pdb
PDB entry 1i71 coloured by chain, front view.
PDB entry 1i71 coloured by chain, side view.
PDB entry 1i71 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
High-resolution crystal structure of apolipoprotein(a) kringle IV type 7: insights into ligand binding.
Ye Q, Rahman MN, Koschinsky ML, Jia Z
Protein Sci 10 1124-9 (2001)
PMID: 11369850

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140162 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Apolipoprotein(a) Chain: A
Molecule details ›
Chain: A
Length: 83 amino acids
Theoretical weight: 9.78 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P08519 (Residues: 1273-1355; Coverage: 4%)
Gene name: LPA
Sequence domains: Kringle domain
Structure domains: Plasminogen Kringle 4

Ligands and Environments

1 bound ligand:
Ligand SO4 1 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE A1
Spacegroup: P212121
Unit cell:
a: 35.11Å b: 40.49Å c: 65.46Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.173 0.173 0.2
Expression system: Escherichia coli

Quick links

Citations

3 review citations

Lipoprotein (a): truly a direct prothrombotic factor in cardiovascular disease?
Boffa et al. (2016)
2 more

12 mentions without citation

Fast and anisotropic flexibility-rigidity index for protein flexibility and fluctuation analysis.
Opron et al. (2014)
11 more