› 1ic1

X-ray diffraction
3Å resolution

THE CRYSTAL STRUCTURE FOR THE N-TERMINAL TWO DOMAINS OF ICAM-1

Released:
DOI: 10.2210/pdb1ic1/pdb
PDB entry 1ic1 coloured by chain, front view.
PDB entry 1ic1 coloured by chain, side view.
PDB entry 1ic1 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
A dimeric crystal structure for the N-terminal two domains of intercellular adhesion molecule-1.
Casasnovas JM, Stehle T, Liu JH, Wang JH, Springer TA
Proc Natl Acad Sci U S A 95 4134-9 (1998)
PMID: 9539702

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138635 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Intercellular adhesion molecule 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 190 amino acids
Theoretical weight: 20.92 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P05362 (Residues: 28-217; Coverage: 38%)
Gene name: ICAM1
Sequence domains: Intercellular adhesion molecule (ICAM), N-terminal domain
Structure domains: Immunoglobulins

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
1 bound ligand:
Ligand NAG 5 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P2
Unit cell:
a: 88Å b: 42.2Å c: 93Å
α: 90° β: 109.3° γ: 90°
R-values:
R R work R free
0.222 0.222 0.279
Expression system: Cricetulus griseus

Quick links

Citations

26 review citations

Conformational regulation of integrin structure and function.
Shimaoka et al. (2002)
25 more

18 mentions without citation

A dimeric crystal structure for the N-terminal two domains of intercellular adhesion molecule-1.
Casasnovas et al. (1998)
17 more