› 1ifr

X-ray diffraction
1.4Å resolution

Structure of Lamin A/C Globular Domain

Released:
DOI: 10.2210/pdb1ifr/pdb
PDB entry 1ifr coloured by chain, front view.
PDB entry 1ifr coloured by chain, side view.
PDB entry 1ifr coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of the globular tail of nuclear lamin.
Dhe-Paganon S, Werner ED, Chi YI, Shoelson SE
J Biol Chem 277 17381-4 (2002)
PMID: 11901143

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-135892 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Lamin-A/C Chain: A
Molecule details ›
Chain: A
Length: 121 amino acids
Theoretical weight: 13.39 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P02545 (Residues: 436-552; Coverage: 18%)
Gene names: LMN1, LMNA
Sequence domains: Lamin Tail Domain
Structure domains: Lamin Tail domain

Ligands and Environments

1 bound ligand:
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X25
Spacegroup: P212121
Unit cell:
a: 26.43Å b: 52.55Å c: 67.44Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.216 0.216 not available
Expression system: Escherichia coli

Quick links

Citations

62 review citations

Nuclear lamins: major factors in the structural organization and function of the nucleus and chromatin.
Dechat et al. (2008)
61 more

32 mentions without citation

The lamin protein family.
Dittmer et al. (2011)
31 more