› 1iip

X-ray diffraction
2Å resolution

Bovine Cyclophilin 40, Tetragonal Form

Released:
DOI: 10.2210/pdb1iip/pdb
PDB entry 1iip coloured by chain, front view.
PDB entry 1iip coloured by chain, side view.
PDB entry 1iip coloured by chain, top view.
Source organism: Bos taurus
Primary publication:
Two structures of cyclophilin 40: folding and fidelity in the TPR domains.
Taylor P, Dornan J, Carrello A, Minchin RF, Ratajczak T, Walkinshaw MD
Structure 9 431-8 (2001)
PMID: 11377203

Function and Biology Details

Reaction catalysed: 
Peptidylproline (omega=180) = peptidylproline (omega=0)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo tetramer
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-150869 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peptidyl-prolyl cis-trans isomerase D Chain: A
Molecule details ›
Chain: A
Length: 370 amino acids
Theoretical weight: 40.68 KDa
Source organism: Bos taurus
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P26882 (Residues: 1-370; Coverage: 100%)
Gene names: CYPD, PPID
Sequence domains: Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SRS BEAMLINE PX9.6
Spacegroup: P4222
Unit cell:
a: 94.585Å b: 94.585Å c: 118.326Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.236 0.236 0.305
Expression system: Escherichia coli BL21

Quick links

Citations

15 review citations

The cyclophilins.
Wang et al. (2005)
14 more

4 mentions without citation

Human cyclophilin 40 unravels neurotoxic amyloids.
Baker et al. (2017)
3 more