› 1ij9

X-ray diffraction
3Å resolution

Highly Hydrated Human VCAM-1 Fragment

Released:
DOI: 10.2210/pdb1ij9/pdb
PDB entry 1ij9 coloured by chain, front view.
PDB entry 1ij9 coloured by chain, side view.
PDB entry 1ij9 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
A new conformation of the integrin-binding fragment of human VCAM-1 crystallizes in a highly hydrated packing arrangement.
Taylor P, Bilsland M, Walkinshaw MD
Acta Crystallogr D Biol Crystallogr 57 1579-83 (2001)
PMID: 11679722

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148551 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Soluble Vascular Cell Adhesion Molecule-1 Chain: A
Molecule details ›
Chain: A
Length: 196 amino acids
Theoretical weight: 21.89 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P19320 (Residues: 25-220; Coverage: 27%)
Gene name: VCAM1
Sequence domains:
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ENRAF-NONIUS FR571
Spacegroup: P3121
Unit cell:
a: 152.939Å b: 152.939Å c: 45.976Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.208 0.208 0.238
Expression system: Escherichia coli

Quick links

Citations

2 review citations

Roles of integrin activation in eosinophil function and the eosinophilic inflammation of asthma.
Barthel et al. (2008)
1 more

6 mentions without citation

Structure of the three N-terminal immunoglobulin domains of the highly immunogenic outer capsid protein from a T4-like bacteriophage.
Fokine et al. (2011)
5 more