› 1ijb

X-ray diffraction
1.8Å resolution

The von Willebrand Factor mutant (I546V) A1 domain

Released:
DOI: 10.2210/pdb1ijb/pdb
PDB entry 1ijb coloured by chain, front view.
PDB entry 1ijb coloured by chain, side view.
PDB entry 1ijb coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis of von Willebrand factor activation by the snake toxin botrocetin.
Fukuda K, Doggett TA, Bankston LA, Cruz MA, Diacovo TG, Liddington RC
Structure 10 943-50 (2002)
PMID: 12121649

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-137563 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
von Willebrand factor Chain: A
Molecule details ›
Chain: A
Length: 202 amino acids
Theoretical weight: 23.13 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P04275 (Residues: 1263-1464; Coverage: 7%)
Gene names: F8VWF, VWF
Sequence domains: von Willebrand factor type A domain
Structure domains: von Willebrand factor, type A domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL7-1
Spacegroup: P61
Unit cell:
a: 86.01Å b: 86.01Å c: 68.502Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.188 0.188 0.208
Expression system: Escherichia coli

Quick links

Citations

17 review citations

Haemostatically active proteins in snake venoms.
Sajevic et al. (2011)
16 more

9 mentions without citation

Molecular biology, genetics and biochemistry of the repulsive guidance molecule family.
Severyn et al. (2009)
8 more