› 1ijr

X-ray diffraction
2.2Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138948 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein kinase Lck Chain: A
Molecule details ›
Chain: A
Length: 104 amino acids
Theoretical weight: 11.83 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P06239 (Residues: 123-226; Coverage: 20%)
Gene name: LCK
Sequence domains: SH2 domain
Structure domains: SH2 domain

Ligands and Environments

1 bound ligand:
Ligand CC0 1 x CC0
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: P43212
Unit cell:
a: 61.6Å b: 61.6Å c: 93.5Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.23 0.23 0.28
Expression system: Escherichia coli

Quick links

Citations

1 review citation

Post-Translational Modifications of Cytochrome c in Cell Life and Disease.
Guerra-Castellano et al. (2020)
6 other articles

4 mentions without citation

Structural snapshots of full-length Jak1, a transmembrane gp130/IL-6/IL-6Rα cytokine receptor complex, and the receptor-Jak1 holocomplex.
Lupardus et al. (2011)
3 more