› 1ijt

X-ray diffraction
1.8Å resolution

Crystal Structure of Fibroblast Growth Factor 4 (FGF4)

Released:
DOI: 10.2210/pdb1ijt/pdb
PDB entry 1ijt coloured by chain, front view.
PDB entry 1ijt coloured by chain, side view.
PDB entry 1ijt coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Identification of receptor and heparin binding sites in fibroblast growth factor 4 by structure-based mutagenesis.
Bellosta P, Iwahori A, Plotnikov AN, Eliseenkova AV, Basilico C, Mohammadi M
Mol Cell Biol 21 5946-57 (2001)
PMID: 11486033

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140240 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Fibroblast growth factor 4 Chain: A
Molecule details ›
Chain: A
Length: 128 amino acids
Theoretical weight: 14.27 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P08620 (Residues: 79-206; Coverage: 73%)
Gene names: FGF4, HST, HSTF1, KS3
Sequence domains: Fibroblast growth factor
Structure domains: Trefoil (Acidic Fibroblast Growth Factor, subunit A)

Ligands and Environments

1 bound ligand:
Ligand SO4 3 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4A
Spacegroup: P212121
Unit cell:
a: 40.367Å b: 53.295Å c: 56.231Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.194 0.194 0.207
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

8 review citations

Structural basis for fibroblast growth factor receptor activation.
Mohammadi et al. (2005)
7 more

13 mentions without citation

Molecular insights into the klotho-dependent, endocrine mode of action of fibroblast growth factor 19 subfamily members.
Goetz et al. (2007)
12 more