› 1ijv

X-ray diffraction
1.2Å resolution

HUMAN BETA-DEFENSIN-1

Released:
DOI: 10.2210/pdb1ijv/pdb
PDB entry 1ijv coloured by chain, front view.
PDB entry 1ijv coloured by chain, side view.
PDB entry 1ijv coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The structure of human beta-defensin-1: new insights into structural properties of beta-defensins.
Hoover DM, Chertov O, Lubkowski J
J Biol Chem 276 39021-6 (2001)
PMID: 11486002

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domain:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-157949 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Beta-defensin 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 36 amino acids
Theoretical weight: 3.94 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P60022 (Residues: 33-68; Coverage: 77%)
Gene names: BD1, DEFB1, HBD1
Sequence domains: Beta defensin

Ligands and Environments

3 bound ligands:
Ligand SO4 2 x SO4
Ligand BR 6 x BR
Ligand K 1 x K
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X9B
Spacegroup: P212121
Unit cell:
a: 27.121Å b: 47.243Å c: 53.853Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.157 0.161 0.193
Expression system: Not provided

Quick links

Citations

27 review citations

Defensins of vertebrate animals.
Lehrer et al. (2002)
26 more

16 mentions without citation

Peptides and Peptidomimetics for Antimicrobial Drug Design.
Mojsoska et al. (2015)
15 more