› 1ilk

X-ray diffraction
1.8Å resolution

INTERLEUKIN-10 CRYSTAL STRUCTURE REVEALS THE FUNCTIONAL DIMER WITH AN UNEXPECTED TOPOLOGICAL SIMILARITY TO INTERFERON GAMMA

Released:
DOI: 10.2210/pdb1ilk/pdb
PDB entry 1ilk coloured by chain, front view.
PDB entry 1ilk coloured by chain, side view.
PDB entry 1ilk coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of interleukin-10 reveals the functional dimer with an unexpected topological similarity to interferon gamma.
Zdanov A, Schalk-Hihi C, Gustchina A, Tsang M, Weatherbee J, Wlodawer A
Structure 3 591-601 (1995)
PMID: 8590020

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-149579 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Interleukin-10 Chain: A
Molecule details ›
Chain: A
Length: 151 amino acids
Theoretical weight: 17.8 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P22301 (Residues: 28-178; Coverage: 94%)
Gene name: IL10
Sequence domains: Interleukin 10
Structure domains: Growth Hormone; Chain: A;

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P3221
Unit cell:
a: 70.274Å b: 70.274Å c: 70.308Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.156 0.156 not available
Expression system: Escherichia coli

Quick links

Citations

43 review citations

Interleukin-10 and the interleukin-10 receptor.
Moore et al. (2001)
42 more

16 mentions without citation

Structural analysis of cytokines comprising the IL-10 family.
Zdanov A. (2010)
15 more