› 1iu2

Solution NMR

The first PDZ domain of PSD-95

Released:
DOI: 10.2210/pdb1iu2/pdb
PDB entry 1iu2 coloured by chain, ensemble of 50 models, front view.
PDB entry 1iu2 coloured by chain, ensemble of 50 models, side view.
PDB entry 1iu2 coloured by chain, ensemble of 50 models, top view.
Source organism: Rattus norvegicus
Primary publication:
Supramodular structure and synergistic target binding of the N-terminal tandem PDZ domains of PSD-95.
Long JF, Tochio H, Wang P, Fan JS, Sala C, Niethammer M, Sheng M, Zhang M
J Mol Biol 327 203-14 (2003)
PMID: 12614619

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151877 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Disks large homolog 4 Chain: A
Molecule details ›
Chain: A
Length: 91 amino acids
Theoretical weight: 9.84 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: P31016 (Residues: 61-151; Coverage: 13%)
Gene names: Dlg4, Dlgh4, Psd95
Sequence domains: PDZ domain
Structure domains: Pdz3 Domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Escherichia coli

Quick links

Citations

20 review citations

PDZ domain proteins of synapses.
Kim et al. (2004)
19 more

4 mentions without citation

Structural conservation of druggable hot spots in protein-protein interfaces.
Kozakov et al. (2011)
3 more