› 1iw2

X-ray diffraction
1.9Å resolution

X-ray structure of Human Complement Protein C8gamma at pH=7.O

Released:
DOI: 10.2210/pdb1iw2/pdb
PDB entry 1iw2 coloured by chain, front view.
PDB entry 1iw2 coloured by chain, side view.
PDB entry 1iw2 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of human complement protein C8gamma at 1.2 A resolution reveals a lipocalin fold and a distinct ligand binding site.
Ortlund E, Parker CL, Schreck SF, Ginell S, Minor W, Sodetz JM, Lebioda L
Biochemistry 41 7030-7 (2002)
PMID: 12033936

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139566 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Complement component C8 gamma chain Chain: A
Molecule details ›
Chain: A
Length: 182 amino acids
Theoretical weight: 20.31 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P07360 (Residues: 21-202; Coverage: 100%)
Gene name: C8G
Sequence domains: Lipocalin / cytosolic fatty-acid binding protein family
Structure domains: Lipocalin

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: P212121
Unit cell:
a: 42.14Å b: 58.904Å c: 71.214Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.233 0.233 0.25
Expression system: Trichoplusia ni

Quick links

Citations

4 review citations

Hemoglobin and heme scavenging.
Ascenzi et al. (2005)
3 more

2 mentions without citation

Staphostatins resemble lipocalins, not cystatins in fold.
Rzychon et al. (2003)
1 more