› 1jgn

Solution NMR

Solution structure of the C-terminal PABC domain of human poly(A)-binding protein in complex with the peptide from Paip2

Released:
DOI: 10.2210/pdb1jgn/pdb
PDB entry 1jgn coloured by chain, ensemble of 30 models, front view.
PDB entry 1jgn coloured by chain, ensemble of 30 models, side view.
PDB entry 1jgn coloured by chain, ensemble of 30 models, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis of ligand recognition by PABC, a highly specific peptide-binding domain found in poly(A)-binding protein and a HECT ubiquitin ligase.
Kozlov G, De Crescenzo G, Lim NS, Siddiqui N, Fantus D, Kahvejian A, Trempe JF, Elias D, Ekiel I, Sonenberg N, O'Connor-McCourt M, Gehring K
EMBO J 23 272-81 (2004)
PMID: 14685257

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145999 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Polyadenylate-binding protein 1 Chain: A
Molecule details ›
Chain: A
Length: 98 amino acids
Theoretical weight: 10.35 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P11940 (Residues: 544-636; Coverage: 15%)
Gene names: PAB1, PABP, PABP1, PABPC1, PABPC2
Sequence domains: Poly-adenylate binding protein, unique domain
Structure domains: c-terminal domain of poly(a) binding protein
Polyadenylate-binding protein-interacting protein 2 Chain: B
Molecule details ›
Chain: B
Length: 22 amino acids
Theoretical weight: 2.39 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9BPZ3 (Residues: 106-127; Coverage: 17%)
Gene names: HSPC218, PAIP2, PAIP2A
Sequence domains: Ataxin-2 C-terminal region

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Escherichia coli

Quick links

Citations

17 review citations

Regulation of mRNA translation and stability by microRNAs.
Fabian et al. (2010)
16 more

3 mentions without citation

LARP1 and LARP4: up close with PABP for mRNA 3' poly(A) protection and stabilization.
Mattijssen et al. (2021)
2 more