› 1jhj

X-ray diffraction
1.6Å resolution

Crystal structure of the APC10/Doc1 subunit of the human anaphase-promoting complex

Released:
DOI: 10.2210/pdb1jhj/pdb
PDB entry 1jhj coloured by chain, front view.
PDB entry 1jhj coloured by chain, side view.
PDB entry 1jhj coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of the APC10/DOC1 subunit of the human anaphase-promoting complex.
Wendt KS, Vodermaier HC, Jacob U, Gieffers C, Gmachl M, Peters JM, Huber R, Sondermann P
Nat Struct Biol 8 784-8 (2001)
PMID: 11524682

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193953 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Anaphase-promoting complex subunit 10 Chain: A
Molecule details ›
Chain: A
Length: 171 amino acids
Theoretical weight: 19.5 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9UM13 (Residues: 2-172; Coverage: 92%)
Gene names: ANAPC10, APC10
Sequence domains: Anaphase-promoting complex, subunit 10 (APC10)
Structure domains: Galactose-binding domain-like

Ligands and Environments

1 bound ligand:
Ligand NI 1 x NI
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: MPG/DESY, HAMBURG BEAMLINE BW6
Spacegroup: P622
Unit cell:
a: 97.664Å b: 97.664Å c: 67.769Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.209 0.209 0.244
Expression system: Escherichia coli

Quick links

Citations

12 review citations

The anaphase promoting complex/cyclosome: a machine designed to destroy.
Peters JM. (2006)
11 more

12 mentions without citation

Panta rhei: the APC/C at steady state.
Primorac et al. (2013)
11 more