› 1jj7

X-ray diffraction
2.4Å resolution

Crystal Structure of the C-terminal ATPase domain of human TAP1

Released:
DOI: 10.2210/pdb1jj7/pdb
PDB entry 1jj7 coloured by chain, front view.
PDB entry 1jj7 coloured by chain, side view.
PDB entry 1jj7 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of the ABC ATPase domain of human TAP1, the transporter associated with antigen processing.
Gaudet R, Wiley DC
EMBO J 20 4964-72 (2001)
PMID: 11532960

Function and Biology Details

Reaction catalysed: 
ATP + H(2)O + antigen peptide(Side 1) = ADP + phosphate + antigen peptide(Side 2)
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-169910 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Antigen peptide transporter 1 Chain: A
Molecule details ›
Chain: A
Length: 260 amino acids
Theoretical weight: 28.13 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q03518 (Residues: 489-748; Coverage: 35%)
Gene names: ABCB2, PSF1, RING4, TAP1, Y3
Sequence domains: ABC transporter
Structure domains: P-loop containing nucleotide triphosphate hydrolases

Ligands and Environments

2 bound ligands:
Ligand MG 1 x MG
Ligand ADP 1 x ADP
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 14-BM-C
Spacegroup: P62
Unit cell:
a: 87.57Å b: 87.57Å c: 79.85Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.198 0.198 0.24
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

46 review citations

Pathways of antigen processing.
Blum et al. (2013)
45 more

19 mentions without citation

Structure of nucleotide-binding domain 1 of the cystic fibrosis transmembrane conductance regulator.
Lewis et al. (2004)
18 more