› 1jkw

X-ray diffraction
2.6Å resolution

STRUCTURE OF CYCLIN MCS2

Released:
DOI: 10.2210/pdb1jkw/pdb
PDB entry 1jkw coloured by chain, front view.
PDB entry 1jkw coloured by chain, side view.
PDB entry 1jkw coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The crystal structure of human cyclin H.
Andersen G, Poterszman A, Egly JM, Moras D, Thierry JC
FEBS Lett 397 65-9 (1996)
PMID: 8941715

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156436 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cyclin-H Chain: A
Molecule details ›
Chain: A
Length: 323 amino acids
Theoretical weight: 37.68 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P51946 (Residues: 1-323; Coverage: 100%)
Gene name: CCNH
Sequence domains:
Structure domains: Cyclin-like

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: LURE
Spacegroup: I4122
Unit cell:
a: 84.06Å b: 84.06Å c: 373.3Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.222 0.222 0.272
Expression system: Escherichia coli

Quick links

Citations

6 review citations

Regulation of Cdc28 cyclin-dependent protein kinase activity during the cell cycle of the yeast Saccharomyces cerevisiae.
Mendenhall et al. (1998)
5 more

8 mentions without citation

Structural insights into the functional diversity of the CDK-cyclin family.
Wood et al. (2018)
7 more