› 1jl4

X-ray diffraction
4.3Å resolution

CRYSTAL STRUCTURE OF THE HUMAN CD4 N-TERMINAL TWO DOMAIN FRAGMENT COMPLEXED TO A CLASS II MHC MOLECULE

Released:
DOI: 10.2210/pdb1jl4/pdb
PDB entry 1jl4 coloured by chain, front view.
PDB entry 1jl4 coloured by chain, side view.
PDB entry 1jl4 coloured by chain, top view.
Source organisms:
Primary publication:
Crystal structure of the human CD4 N-terminal two-domain fragment complexed to a class II MHC molecule.
Wang JH, Meijers R, Xiong Y, Liu JH, Sakihama T, Zhang R, Joachimiak A, Reinherz EL
Proc Natl Acad Sci U S A 98 10799-804 (2001)
PMID: 11535811

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
PDBe Complex ID:
PDB-CPX-134523 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
H-2 class II histocompatibility antigen, A-K alpha chain Chain: A
Molecule details ›
Chain: A
Length: 178 amino acids
Theoretical weight: 20.43 KDa
Source organism: Mus musculus
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P01910 (Residues: 31-208; Coverage: 76%)
Gene name: H2-Aa
Sequence domains:
H-2 class II histocompatibility antigen, A-K beta chain Chain: B
Molecule details ›
Chain: B
Length: 185 amino acids
Theoretical weight: 21.89 KDa
Source organism: Mus musculus
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P06343 (Residues: 34-216; Coverage: 78%)
Gene name: H2-Ab1
Sequence domains:
Ovotransferrin Chain: C
Molecule details ›
Chain: C
Length: 16 amino acids
Theoretical weight: 1.7 KDa
Source organism: Gallus gallus
Expression system: Gallus gallus
UniProt:
  • Canonical: P02789 (Residues: 153-165; Coverage: 2%)
T-cell surface glycoprotein CD4 Chain: D
Molecule details ›
Chain: D
Length: 178 amino acids
Theoretical weight: 19.73 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P01730 (Residues: 26-203; Coverage: 41%)
Gene name: CD4
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P4322
Unit cell:
a: 145.195Å b: 145.195Å c: 103.846Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.428 0.42 0.453
Expression systems:
  • Cricetulus griseus
  • Gallus gallus

Quick links

Citations

41 review citations

How TCRs bind MHCs, peptides, and coreceptors.
Rudolph et al. (2006)
40 more

17 mentions without citation

The structural basis of αβ T-lineage immune recognition: TCR docking topologies, mechanotransduction, and co-receptor function.
Wang et al. (2012)
16 more