1jma

X-ray diffraction
2.65Å resolution

CRYSTAL STRUCTURE OF THE HERPES SIMPLEX VIRUS GLYCOPROTEIN D BOUND TO THE CELLULAR RECEPTOR HVEA/HVEM

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-157600 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (3 distinct):
Tumor necrosis factor receptor superfamily member 14 Chain: B
Molecule details ›
Chain: B
Length: 167 amino acids
Theoretical weight: 17.77 KDa
Source organism: Human alphaherpesvirus 1
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q92956 (Residues: 39-200; Coverage: 66%)
Gene names: HVEA, HVEM, TNFRSF14, UNQ329/PRO509
Sequence domains: TNFR/NGFR cysteine-rich region
Structure domains: Tumor Necrosis Factor Receptor, subunit A, domain 2
Envelope glycoprotein D Chain: A
Molecule details ›
Chain: A
Length: 290 amino acids
Theoretical weight: 32.32 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P57083 (Residues: 26-310; Coverage: 77%)
Gene names: US6, gD
Sequence domains: Herpesvirus glycoprotein D/GG/GX domain
Structure domains: Glycoprotein D; Chain: A;

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE A1
Spacegroup: P3121
Unit cell:
a: 129.154Å b: 129.154Å c: 80.94Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.237 0.236 0.259
Expression system: Spodoptera frugiperda