Function and Biology Details
Reaction catalysed:
Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B.
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:
Structure analysis Details
Assembly composition:
hetero trimer (preferred)
Assembly name:
alpha-thrombin complex and Heparin cofactor 2 (preferred)
PDBe Complex ID:
PDB-CPX-133070 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (4 distinct):
Thrombin light chain
Molecule details ›
Chain: L
Length: 48 amino acids
Theoretical weight: 5.48 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
Sequence domains: Thrombin light chain
Structure domains: Thrombin light chain domain
Length: 48 amino acids
Theoretical weight: 5.48 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
- Canonical:
P00734 (Residues: 315-362; Coverage: 8%)
Sequence domains: Thrombin light chain
Structure domains: Thrombin light chain domain
Thrombin heavy chain
Molecule details ›
Chain: H
Length: 260 amino acids
Theoretical weight: 29.92 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases
Length: 260 amino acids
Theoretical weight: 29.92 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
- Canonical: P00734 (Residues: 363-622; Coverage: 44%)
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases
Heparin cofactor 2
Molecule details ›
Chain: A
Length: 480 amino acids
Theoretical weight: 55.19 KDa
Source organism: Homo sapiens
UniProt:
Sequence domains: Serpin (serine protease inhibitor)
Structure domains:
Length: 480 amino acids
Theoretical weight: 55.19 KDa
Source organism: Homo sapiens
UniProt:
- Canonical: P05546 (Residues: 20-499; Coverage: 100%)
Sequence domains: Serpin (serine protease inhibitor)
Structure domains:
