› 1jnj

Solution NMR

NMR solution structure of the human beta2-microglobulin

Released:
DOI: 10.2210/pdb1jnj/pdb
PDB entry 1jnj coloured by chain, ensemble of 20 models, front view.
PDB entry 1jnj coloured by chain, ensemble of 20 models, side view.
PDB entry 1jnj coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
The solution structure of human beta2-microglobulin reveals the prodromes of its amyloid transition.
Verdone G, Corazza A, Viglino P, Pettirossi F, Giorgetti S, Mangione P, Andreola A, Stoppini M, Bellotti V, Esposito G
Protein Sci 11 487-99 (2002)
PMID: 11847272

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-158314 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Beta-2-microglobulin Chain: A
Molecule details ›
Chain: A
Length: 100 amino acids
Theoretical weight: 11.88 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P61769 (Residues: 21-119; Coverage: 100%)
Gene names: B2M, CDABP0092, HDCMA22P
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing, restrained molecular dynamics, restrained molecular mechanics
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

10 review citations

Molecular mechanisms of amyloidosis.
Merlini et al. (2003)
9 more

29 mentions without citation

Understanding the complex mechanisms of β2-microglobulin amyloid assembly.
Eichner et al. (2011)
28 more