› 1jqh

X-ray diffraction
2.1Å resolution

IGF-1 receptor kinase domain

Released:
DOI: 10.2210/pdb1jqh/pdb
PDB entry 1jqh coloured by chain, front view.
PDB entry 1jqh coloured by chain, side view.
PDB entry 1jqh coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of bisphosphorylated IGF-1 receptor kinase: insight into domain movements upon kinase activation.
Pautsch A, Zoephel A, Ahorn H, Spevak W, Hauptmann R, Nar H
Structure 9 955-65 (2001)
PMID: 11591350

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139909 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Insulin-like growth factor 1 receptor beta chain Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 308 amino acids
Theoretical weight: 35.1 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P08069 (Residues: 979-1286; Coverage: 23%)
Gene name: IGF1R
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

3 bound ligands:
Ligand MG 1 x MG
Ligand SO4 3 x SO4
Ligand ANP 3 x ANP
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: MPG/DESY, HAMBURG BEAMLINE BW6
Spacegroup: P32
Unit cell:
a: 85.963Å b: 85.963Å c: 132.204Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.195 0.195 0.219
Expression system: Spodoptera frugiperda

Quick links

Citations

12 review citations

The insulin-like growth factor system and cancer.
LeRoith et al. (2003)
11 more

13 mentions without citation

Using multiple microenvironments to find similar ligand-binding sites: application to kinase inhibitor binding.
Liu et al. (2011)
12 more