› 1jr2

X-ray diffraction
1.84Å resolution

Structure of Uroporphyrinogen III Synthase

Released:
DOI: 10.2210/pdb1jr2/pdb
PDB entry 1jr2 coloured by chain, front view.
PDB entry 1jr2 coloured by chain, side view.
PDB entry 1jr2 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of human uroporphyrinogen III synthase.
Mathews MA, Schubert HL, Whitby FG, Alexander KJ, Schadick K, Bergonia HA, Phillips JD, Hill CP
EMBO J 20 5832-9 (2001)
PMID: 11689424

Function and Biology Details

Reaction catalysed: 
Hydroxymethylbilane = uroporphyrinogen III + H(2)O
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145438 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Uroporphyrinogen-III synthase Chains: A, B
Molecule details ›
Chains: A, B
Length: 286 amino acids
Theoretical weight: 31.19 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P10746 (Residues: 1-265; Coverage: 100%)
Gene name: UROS
Sequence domains: Uroporphyrinogen-III synthase HemD
Structure domains: Rossmann fold

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL9-1
Spacegroup: P1
Unit cell:
a: 39.852Å b: 59.251Å c: 61.944Å
α: 80.47° β: 73.32° γ: 88.33°
R-values:
R R work R free
0.203 0.2 0.251
Expression system: Escherichia coli

Quick links

Citations

15 review citations

Biosynthesis of heme in mammals.
Ajioka et al. (2006)
14 more

12 mentions without citation

Mechanisms of protein evolution.
Jayaraman et al. (2022)
11 more