Function and Biology Details
Reactions catalysed:
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)
Hydrolysis of four peptide bonds in the viral precursor polyprotein, commonly with Asp or Glu in the P6 position, Cys or Thr in P1 and Ser or Ala in P1'.
NTP + H(2)O = NDP + phosphate
ATP + H(2)O = ADP + phosphate
Biochemical function:
- not assigned
Biological process:
- not assigned
Cellular component:
- not assigned
Sequence domains:
Structure domain:
Structure analysis Details
Assembly composition:
monomeric (preferred)
Assembly name:
Protease NS2 (preferred)
PDBe Complex ID:
PDB-CPX-151107 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine protease/helicase NS3
Molecule details ›
Chain: A
Length: 142 amino acids
Theoretical weight: 15.15 KDa
Source organism: Hepacivirus C
Expression system: Escherichia coli BL21(DE3)
UniProt:
Length: 142 amino acids
Theoretical weight: 15.15 KDa
Source organism: Hepacivirus C
Expression system: Escherichia coli BL21(DE3)
UniProt:
- Canonical:
P27958 (Residues: 1353-1507; Coverage: 5%)
Ligands and Environments
No bound ligands
No modified residues
Experiments and Validation Details
Refinement method:
simulated annealing
Expression system: Escherichia coli BL21(DE3)
