› 1jvk

X-ray diffraction
1.94Å resolution

THREE-DIMENSIONAL STRUCTURE OF AN IMMUNOGLOBULIN LIGHT CHAIN DIMER ACTING AS A LETHAL AMYLOID PRECURSOR

Released:
DOI: 10.2210/pdb1jvk/pdb
PDB entry 1jvk coloured by chain, front view.
PDB entry 1jvk coloured by chain, side view.
PDB entry 1jvk coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Three-dimensional structure of an immunoglobulin light-chain dimer with amyloidogenic properties.
Bourne PC, Ramsland PA, Shan L, Fan ZC, DeWitt CR, Shultz BB, Terzyan SS, Moomaw CR, Slaughter CA, Guddat LW, Edmundson AB
Acta Crystallogr D Biol Crystallogr 58 815-23 (2002)
PMID: 11976493

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-180184 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ig-like domain-containing protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 216 amino acids
Theoretical weight: 22.61 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q6PJG0 (Residues: 20-117, 118-234; Coverage: 100%)
Sequence domains:
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
1 modified residue:
Ligand PCA 2 x PCA

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P212121
Unit cell:
a: 48.28Å b: 83.32Å c: 112.591Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.223 0.221 0.254

Quick links

Citations

4 review citations

Amyloid formation in light chain amyloidosis.
Ramirez-Alvarado M. (2012)
3 more

7 mentions without citation

Insufficiently dehydrated hydrogen bonds as determinants of protein interactions.
Fernández et al. (2003)
6 more