› 1jxo

X-ray diffraction
2.3Å resolution

Crystal Structure of the SH3-HOOK-GK Fragment of PSD-95

Released:
DOI: 10.2210/pdb1jxo/pdb
PDB entry 1jxo coloured by chain, front view.
PDB entry 1jxo coloured by chain, side view.
PDB entry 1jxo coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Structural characterization of the intramolecular interaction between the SH3 and guanylate kinase domains of PSD-95.
Tavares GA, Panepucci EH, Brunger AT
Mol Cell 8 1313-25 (2001)
PMID: 11779506

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151877 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Disks large homolog 4 Chains: A, B
Molecule details ›
Chains: A, B
Length: 301 amino acids
Theoretical weight: 34.81 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: P31016 (Residues: 430-724; Coverage: 41%)
Gene names: Dlg4, Dlgh4, Psd95
Sequence domains:
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL11-1
Spacegroup: P1
Unit cell:
a: 45.009Å b: 53.41Å c: 63.262Å
α: 89.96° β: 90° γ: 91.78°
R-values:
R R work R free
0.22 0.22 0.264
Expression system: Escherichia coli

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Citations

22 review citations

PDZ domain proteins of synapses.
Kim et al. (2004)
21 more

5 mentions without citation

Neuroligins and neurexins link synaptic function to cognitive disease.
Südhof TC. (2008)
4 more