› 1jy0

X-ray diffraction
1.7Å resolution

Human acidic fibroblast growth factor. 141 amino acid form with amino terminal His tag and Cys 117 replaced with Val (C117V).

Released:
DOI: 10.2210/pdb1jy0/pdb
PDB entry 1jy0 coloured by chain, front view.
PDB entry 1jy0 coloured by chain, side view.
PDB entry 1jy0 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Accommodation of a highly symmetric core within a symmetric protein superfold.
Brych SR, Kim J, Logan TM, Blaber M
Protein Sci 12 2704-18 (2003)
PMID: 14627732

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138603 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Fibroblast growth factor 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 146 amino acids
Theoretical weight: 16.68 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P05230 (Residues: 16-155; Coverage: 90%)
Gene names: FGF1, FGFA
Sequence domains: Fibroblast growth factor
Structure domains: Trefoil (Acidic Fibroblast Growth Factor, subunit A)

Ligands and Environments

1 bound ligand:
Ligand FMT 3 x FMT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: C2221
Unit cell:
a: 74.23Å b: 96.222Å c: 109.004Å
α: 90° β: 90° γ: 90°
Expression system: Escherichia coli

Quick links

Citations

1 review citation

Emergence of symmetric protein architecture from a simple peptide motif: evolutionary models.
Blaber et al. (2012)
16 other articles

3 mentions without citation

Structural and biochemical characterization of SrcA, a multi-cargo type III secretion chaperone in Salmonella required for pathogenic association with a host.
Cooper et al. (2010)
2 more