› 1k36

Solution NMR

NMR Structure of human Epiregulin

Released:
DOI: 10.2210/pdb1k36/pdb
PDB entry 1k36 coloured by chain, ensemble of 40 models, front view.
PDB entry 1k36 coloured by chain, ensemble of 40 models, side view.
PDB entry 1k36 coloured by chain, ensemble of 40 models, top view.
Source organism: Homo sapiens
Primary publication:
Solution structure of epiregulin and the effect of its C-terminal domain for receptor binding affinity.
Sato K, Nakamura T, Mizuguchi M, Miura K, Tada M, Aizawa T, Gomi T, Miyamoto K, Kawano K
FEBS Lett 553 232-8 (2003)
PMID: 14572630

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127216 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Epiregulin Chain: A
Molecule details ›
Chain: A
Length: 46 amino acids
Theoretical weight: 5.28 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O14944 (Residues: 63-108; Coverage: 33%)
Gene name: EREG
Structure domains: Laminin

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: distance geometry simulated annealing
Expression system: Escherichia coli

Quick links

Citations

2 review citations

Role of Epidermal Growth Factor Receptor (EGFR) and Its Ligands in Kidney Inflammation and Damage.
Rayego-Mateos et al. (2018)
1 more

6 mentions without citation

EGFR Ligands Differentially Stabilize Receptor Dimers to Specify Signaling Kinetics.
Freed et al. (2017)
5 more