› 1k59

X-ray diffraction
1.8Å resolution

Crystal Structure of Human Angiogenin Variant Q117G

Released:
DOI: 10.2210/pdb1k59/pdb
PDB entry 1k59 coloured by chain, front view.
PDB entry 1k59 coloured by chain, side view.
PDB entry 1k59 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystallographic studies on the role of the C-terminal segment of human angiogenin in defining enzymatic potency.
Leonidas DD, Shapiro R, Subbarao GV, Russo A, Acharya KR
Biochemistry 41 2552-62 (2002)
PMID: 11851402

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-137273 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Angiogenin Chain: A
Molecule details ›
Chain: A
Length: 123 amino acids
Theoretical weight: 14.08 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P03950 (Residues: 25-147; Coverage: 100%)
Gene names: ANG, RNASE5
Sequence domains: Pancreatic ribonuclease
Structure domains: Ribonuclease A-like domain

Ligands and Environments

1 bound ligand:
Ligand CIT 1 x CIT
1 modified residue:
Ligand PCA 1 x PCA

Experiments and Validation Details

Entry percentile scores
X-ray source: SIEMENS, SRS BEAMLINE PX9.5
Spacegroup: P21212
Unit cell:
a: 86.65Å b: 37.63Å c: 38.78Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.196 0.196 0.241
Expression system: Escherichia coli

Quick links

Citations

2 review citations

Targeting tumor micro-environment for design and development of novel anti-angiogenic agents arresting tumor growth.
Gacche et al. (2013)
1 more

2 mentions without citation

Analysis of the "thermodynamic information content" of a Homo sapiens structural database reveals hierarchical thermodynamic organization.
Larson et al. (2004)
1 more