› 1k8f

X-ray diffraction
2.8Å resolution

CRYSTAL STRUCTURE OF THE HUMAN C-TERMINAL CAP1-ADENYLYL CYCLASE ASSOCIATED PROTEIN

Released:
DOI: 10.2210/pdb1k8f/pdb
PDB entry 1k8f coloured by chain, front view.
PDB entry 1k8f coloured by chain, side view.
PDB entry 1k8f coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of the actin binding domain of the cyclase-associated protein.
Dodatko T, Fedorov AA, Grynberg M, Patskovsky Y, Rozwarski DA, Jaroszewski L, Aronoff-Spencer E, Kondraskina E, Irving T, Godzik A, Almo SC
Biochemistry 43 10628-41 (2004)
PMID: 15311924

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-169580 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Adenylyl cyclase-associated protein 1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 157 amino acids
Theoretical weight: 17.36 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q01518 (Residues: 319-475; Coverage: 33%)
Gene names: CAP, CAP1
Sequence domains: Adenylate cyclase associated (CAP) C terminal
Structure domains: Pectate Lyase C-like

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P212121
Unit cell:
a: 82.64Å b: 83.12Å c: 99.96Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.232 0.232 0.268
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

6 review citations

The yeast actin cytoskeleton: from cellular function to biochemical mechanism.
Moseley et al. (2006)
5 more

10 mentions without citation

Structural genomics: a pipeline for providing structures for the biologist.
Chance et al. (2002)
9 more