› 1kat

Solution NMR

Solution Structure of a Phage-Derived Peptide Antagonist in Complex with Vascular Endothelial Growth Factor

Released:
DOI: 10.2210/pdb1kat/pdb
PDB entry 1kat coloured by chain, ensemble of 24 models, front view.
PDB entry 1kat coloured by chain, ensemble of 24 models, side view.
PDB entry 1kat coloured by chain, ensemble of 24 models, top view.
Source organism: Homo sapiens
Primary publication:
Solution structure of a phage-derived peptide antagonist in complex with vascular endothelial growth factor.
Pan B, Li B, Russell SJ, Tom JY, Cochran AG, Fairbrother WJ
J Mol Biol 316 769-87 (2002)
PMID: 11866530

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-147433 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
N-VEGF Chains: V, W
Molecule details ›
Chains: V, W
Length: 99 amino acids
Theoretical weight: 11.65 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P15692 (Residues: 217-315; Coverage: 25%)
Gene names: VEGF, VEGFA
Structure domains: Cystine-knot cytokines
Phage-Derived Peptide Antagonist Chains: X, Y
Molecule details ›
Chains: X, Y
Length: 19 amino acids
Theoretical weight: 2.35 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: Torsion angle dynamics simulated annealing
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

5 review citations

The role of VEGF receptors in angiogenesis; complex partnerships.
Cébe-Suarez et al. (2006)
4 more

8 mentions without citation

Peptide Inhibitors of Vascular Endothelial Growth Factor A: Current Situation and Perspectives.
Guryanov et al. (2021)
7 more