› 1kgd

X-ray diffraction
1.31Å resolution

Crystal Structure of the Guanylate Kinase-like Domain of Human CASK

Released:
DOI: 10.2210/pdb1kgd/pdb
PDB entry 1kgd coloured by chain, front view.
PDB entry 1kgd coloured by chain, side view.
PDB entry 1kgd coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for nucleotide-dependent regulation of membrane-associated guanylate kinase-like domains.
Li Y, Spangenberg O, Paarmann I, Konrad M, Lavie A
J Biol Chem 277 4159-65 (2002)
PMID: 11729206

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127208 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peripheral plasma membrane protein CASK Chain: A
Molecule details ›
Chain: A
Length: 180 amino acids
Theoretical weight: 20.75 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O14936 (Residues: 739-914; Coverage: 19%)
Gene names: CASK, LIN2
Sequence domains: Guanylate kinase
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand FMT 5 x FMT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 14-BM-D
Spacegroup: P3221
Unit cell:
a: 70.341Å b: 70.341Å c: 74.861Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.188 0.186 0.212
Expression system: Escherichia coli

Quick links

Citations

6 review citations

Emerging roles of pseudokinases.
Boudeau et al. (2006)
5 more

10 mentions without citation

Neuroligins and neurexins link synaptic function to cognitive disease.
Südhof TC. (2008)
9 more