› 1kik

Solution NMR

SH3 Domain of Lymphocyte Specific Kinase (LCK)

Released:
DOI: 10.2210/pdb1kik/pdb
PDB entry 1kik coloured by chain, ensemble of 25 models, front view.
PDB entry 1kik coloured by chain, ensemble of 25 models, side view.
PDB entry 1kik coloured by chain, ensemble of 25 models, top view.
Source organism: Homo sapiens
Primary publication:
Structure determination of human Lck unique and SH3 domains by nuclear magnetic resonance spectroscopy.
Briese L, Willbold D
BMC Struct Biol 3 3 (2003)
PMID: 12734017

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138948 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein kinase Lck Chain: A
Molecule details ›
Chain: A
Length: 57 amino acids
Theoretical weight: 6.41 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P06239 (Residues: 64-120; Coverage: 11%)
Gene name: LCK
Sequence domains: SH3 domain
Structure domains: SH3 Domains

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Escherichia coli BL21

Quick links

Citations

1 review citation

Regulating the discriminatory response to antigen by T-cell receptor.
Gangopadhyay et al. (2022)
6 other articles

3 mentions without citation

Structure of Stenotrophomonas maltophilia FeoA complexed with zinc: a unique prokaryotic SH3-domain protein that possibly acts as a bacterial ferrous iron-transport activating factor.
Su et al. (2010)
2 more