› 1kmf

Solution NMR

NMR STRUCTURE OF HUMAN INSULIN MUTANT ILE-A2-ALLO-ILE, HIS-B10-ASP, PRO-B28-LYS, LYS-B29-PRO, 15 STRUCTURES

Released:
DOI: 10.2210/pdb1kmf/pdb
PDB entry 1kmf coloured by chain, ensemble of 15 models, front view.
PDB entry 1kmf coloured by chain, ensemble of 15 models, side view.
PDB entry 1kmf coloured by chain, ensemble of 15 models, top view.
Source organism: Homo sapiens
Primary publication:
Chiral mutagenesis of insulin's hidden receptor-binding surface: structure of an allo-isoleucine(A2) analogue.
Xu B, Hua QX, Nakagawa SH, Jia W, Chu YC, Katsoyannis PG, Weiss MA
J Mol Biol 316 435-41 (2002)
PMID: 11866509

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-134182 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Insulin A chain Chain: A
Molecule details ›
Chain: A
Length: 21 amino acids
Theoretical weight: 2.38 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P01308 (Residues: 90-110; Coverage: 24%)
Gene name: INS
Insulin B chain Chain: B
Molecule details ›
Chain: B
Length: 30 amino acids
Theoretical weight: 3.41 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P01308 (Residues: 25-54; Coverage: 35%)
Gene name: INS
Sequence domains: Insulin/IGF/Relaxin family

Ligands and Environments

No bound ligands
1 modified residue:
Ligand IIL 1 x IIL

Experiments and Validation Details

Entry percentile scores
Refinement method: Distance geometry and simulated annealing
Expression system: Not provided

Quick links

Citations

3 review citations

Insulin structure and function.
Mayer et al. (2007)
2 more